The Women's Journal

The New Solution To Cellulite

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By Nadiv Shapira, M.D., Fellow, ABVLM

Most of us know that cellulite looks like unsightly, lumpy fat and dimply skin, which usually appears on the buttocks, stomach and thighs of women. What most of us don’t know though, is that there is a new, easy, non-invasive way to get rid of it! 

The science of cellulite

As we gain weight, our fat cells grow in size and push out against the skin. Underneath the skin, we have cords of tough, fibrous bands that tether the skin to the underlying muscle. When the fat cells enlarge, they push against these fibrous cords, which results in the uneven dimples of cellulite.

Do men get cellulite?

The fibrous cords under the skin in men are arranged more horizontally than they are in women, so when fat cells increase in size, they usually do not affect the outer layer of the skin. In women however, these cords are arranged in vertical arches that are fixed to the skin.

Can losing weight get rid of cellulite?

After putting in hours at the gym and resisting those morning muffins, most women will be disappointed to find out that diet and exercise does little to help reduce cellulite. Reducing the volume of the fat cells by weight loss or exercise, may only somewhat improve the appearance of cellulite. 

Does laser work to reduce cellulite?

Women have tried numerous methods throughout the years to help reduce the appearance of cellulite, without much success. Some of these including applying creams, getting laser or radio-frequency energy procedures, and even having surgery where incisions are made in the skin to cut the string-like cords. However, these methods are not very effective or long lasting. Skin tightening by laser or other methods is also not effective because cellulite is not the result of lose skin or laxity.

Introducing QWO, the solution to removing cellulite

A newly released injectable enzyme, Collagenase clostridium histolyticum-aaes, called QWO, has just been proven to break down and remove cellulite for good in the buttocks! It doesn’t reduce the size of the fat cells, as you would imagine. It actually works by breaking down the protein that makes up the fibrous bands that cause the dimpling in cellulite, thereby smoothing out the skin and removing the bumps and dimples. QWO has just been FDA approved for the treatment of moderate to severe cellulite in the buttocks of adult women.

How is QWO administered?

A trained nurse or doctor will inject QWO into the dimples of the cellulite, which will gradually disrupt the cords that hold the fat and which will release the skin to make it appear smooth again. The injection of QWO is done with a tiny needle, so that it is barely felt by the recipient. Just like the injection of Botox, it is associated with minimal discomfort.

Is there any downtime?

There is no downtime after getting treatment with QWO. There may be a few days of local pain, itching, redness, swelling or warmth at the injection site, but these are just temporary. Some people may experience bruising which may last up to 2-3 weeks, so we recommend getting your QWO treatment at least three weeks before going on vacation.

When will I be bikini-ready?

Up to twelve cellulite dimples on each buttock cheek can be treated in one visit. The treatment should be repeated in 21 days and ideally, for a total of three visits. After that, your cellulite will be greatly reduced and for most, it will be gone! So, if you want to have the most beautiful ‘booty’ for the summer of 2022, we recommend that you begin your QWO treatment this spring.

For more information call 302-294-0700 or visit


Dr. Nadiv Shapira is an expert in fat disorder disease and is one of a handful of surgeons in the U.S. that performs a specialized liposuction procedure for Lipedema. Before founding First State Med Spa, Dr. Shapira was a board certified practicing Cardiothoracic Surgeon for over 20 years.